The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression.
نویسندگان
چکیده
The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.
منابع مشابه
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Herpes simplex virus type 1 (HSV-1) protein ICP27 is a multifunctional regulator of gene expression that assumes different roles during the course of infection. Early in infection, ICP27 mediates the inhibition of cellular splicing, whereas, later it helps to recruit cellular RNA polymerase II (RNAP II) to viral replication sites and to facilitate viral RNA export. ICP27 has also been shown to ...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 33 Pt 3 شماره
صفحات -
تاریخ انتشار 2005